Dataset Information

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.

ABSTRACT:

Introduction

Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic functional connectivity changes during glucose loading using functional magnetic resonance imaging (fMRI).

Methods

To do so, we conducted oral glucose tolerance tests while acquiring functional images before, and 10 and 45 min after glucose ingestion in a healthy male and cross-sectionally in 20 healthy participants on two different diets.

Results

At group level, 39 fMRI sessions were not sufficient to detect glucose-mediated connectivity changes. However, 10 repeated sessions in a single subject revealed significant intrinsic functional connectivity increases 45 min after glucose intake in the arcuate, paraventricular, and dorsomedial nuclei, as well as in the posterior hypothalamic area, median eminence, and mammillary bodies.

Discussion

Our methodology allowed to outline glucose-sensitive hypothalamic pathways in a single human being and holds promise in delineating individual pathophysiology mechanisms in patients with dysglycemia.

SUBMITTER: Manuel J

PROVIDER: S-EPMC10749345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.

Manuel Jorge J Halbe Eva E Ewald Ann Charlotte AC Hoff Alex A Jordan Jens J Tank Jens J Heusser Karsten K Gerlach Darius A DA

Frontiers in neuroscience 20231211

<h4>Introduction</h4>Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic functional connectivity changes during glucose loading using functional magnetic resonance imaging (fMRI).<h4>Methods</h4>To do so, we conducted oral glucose tolerance tests while acquiring functional images before, and 10 and 45 min after gl ...[more]

PMID: 38146542

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Dataset Information

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.

Introduction

Methods

Results

Discussion

Publications

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.

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