Dataset Information

The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Helicobacter Pylori Infection to Gastric Cancer.

ABSTRACT:

Background/aim

Elevated serum interleukin-16 (IL-16) levels have been reported in gastric cancer (GC) tissues; however, the role of IL-16 genotypes in GC susceptibility remains largely unexplored. This study aimed to investigate the contribution of IL-16 genotypes to GC susceptibility and to assess their interactions with smoking, alcohol drinking, and Helicobacter pylori (H. pylori) infection.

Materials and methods

Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology was employed to determine IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics in 161 patients with GC and 483 controls.

Results

Significant differences were observed in the distribution of genotypic (p=0.0009) and allelic (p=0.0002) frequencies of IL-16 rs11556218 among cases and controls. Specifically, the frequencies of TG and GG genotypes of IL-16 rs11556218 were 37.3% and 6.8% among patients with GC, respectively, which were higher than those among the controls (26.7% and 2.7%). In contrast, no significant differences were found concerning IL-16 rs4778889 or rs4072111. Notably, individuals with IL-16 rs11556218 TT genotypes exhibited significant protective effects against GC when exposed to risk factors, such as smoking, alcohol drinking, and H. pylori infection.

Conclusion

IL-16 rs11556218 T allele was associated with reduced susceptibility to GC. Furthermore, carriers of the TT genotype showed protection against GC risk factors, including smoking, alcohol drinking, and H. pylori infection. These findings provide valuable insights into the potential role of IL-16 genotypes in GC development and their interactions with lifestyle and infectious factors.

SUBMITTER: Fu CK

PROVIDER: S-EPMC10756437 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature

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The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and <i>Helicobacter Pylori</i> Infection to Gastric Cancer.

Fu Chun-Kai CK Mong Mei-Chin MC Tzeng Huey-En HE Yang Mei-Due MD Chen Jaw-Chyun JC Hsia Te-Chun TC Hsia Ning-Yi NY Tsai Chia-Wen CW Chang Wen-Shin WS Chen Chou-Pin CP Bau DA-Tian DT

In vivo (Athens, Greece) 20240101 1

<h4>Background/aim</h4>Elevated serum interleukin-16 (IL-16) levels have been reported in gastric cancer (GC) tissues; however, the role of IL-16 genotypes in GC susceptibility remains largely unexplored. This study aimed to investigate the contribution of IL-16 genotypes to GC susceptibility and to assess their interactions with smoking, alcohol drinking, and Helicobacter pylori (H. pylori) infection.<h4>Materials and methods</h4>Polymerase chain reaction-based restriction fragment length polym ...[more]

PMID: 38148080

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