Ontology highlight
ABSTRACT: Introduction
Previous neuroimaging studies in social anxiety disorders (SAD) have reported potential neural predictors of cognitive behavioral therapy (CBT)-related brain changes. However, several meta-analyses have demonstrated that cognitive therapy (CT) was superior to traditional exposure-based CBT for SAD.Objective
To explore resting-state functional connectivity (rsFC) to evaluate the response to individual CT for SAD patients.Methods
Twenty SAD patients who attended 16-week individual CT were scanned pre- and post-therapy along with twenty healthy controls (HCs). The severity of social anxiety was assessed with the Liebowitz Social Anxiety Scale (LSAS). Multi-voxel pattern analysis (MVPA) was performed on the pre-CT data to extract regions associated with a change in LSAS (∆LSAS). Group comparisons of the seed-based rsFC analysis were performed between the HCs and pre-CT patients and between the pre-and post-CT patients.Results
MVPA-based regression analysis revealed that rsFC between the left thalamus and the frontal pole/inferior frontal gyrus was significantly correlated with ∆LSAS (adjusted R2 = 0.65; p = 0.00002). Compared with HCs, the pre-CT patients had higher rsFCs between the thalamus and temporal pole and between the thalamus and superior/middle temporal gyrus/planum temporale (p < 0.05). The rsFC between the thalamus and the frontal pole decreased post-CT (p < 0.05).Conclusion
SAD patients had significant rsFC between the thalamus and temporal pole, superior/middle temporal gyrus, and planum temporale, which may be indicators of extreme anxiety in social situations. In addition, rsFC between the thalamus and the frontal pole may be a neuromarker for the effectiveness of individual CT.
SUBMITTER: Kurita K
PROVIDER: S-EPMC10764569 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Kurita Kohei K Obata Takayuki T Sutoh Chihiro C Matsuzawa Daisuke D Yoshinaga Naoki N Kershaw Jeff J Chhatkuli Ritu Bhusal RB Ota Junko J Shimizu Eiji E Hirano Yoshiyuki Y
Frontiers in psychiatry 20231221
<h4>Introduction</h4>Previous neuroimaging studies in social anxiety disorders (SAD) have reported potential neural predictors of cognitive behavioral therapy (CBT)-related brain changes. However, several meta-analyses have demonstrated that cognitive therapy (CT) was superior to traditional exposure-based CBT for SAD.<h4>Objective</h4>To explore resting-state functional connectivity (rsFC) to evaluate the response to individual CT for SAD patients.<h4>Methods</h4>Twenty SAD patients who attende ...[more]