Strategies for mitigating adverse events related to selective RET inhibitors in patients with RET-altered cancers.
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ABSTRACT:
SUBMITTER: Nardo M
PROVIDER: S-EPMC10772460 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Strategies for mitigating adverse events related to selective RET inhibitors in patients with RET-altered cancers.
Nardo Mirella M Gouda Mohamed A MA Nelson Blessie E BE Barreto Carmelia M N CMN Slade J Hoyt JH Poullard Anna A Zafereo Mark M Hu Mimi I MI Cabanillas Maria E ME Subbiah Vivek V
Cell reports. Medicine 20231201 12
The US Food and Drug Administration (FDA) approval of the selective RET inhibitors selpercatinib and pralsetinib has led to a paradigm change in the treatment of RET-altered lung and thyroid cancers through a higher response rate and a more tolerable safety and toxicity profile than multi-kinase inhibitors. Recently, selpercatinib has received a tissue-agnostic FDA approval for all RET-fusion-positive cancers, and pralsetinib has shown pan-cancer activity as well. Given the anticipated increase ...[more]
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