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The Evolving Treatment Landscape of Medullary Thyroid Cancer.

ABSTRACT:

Opinion statement

Genetic assessment is crucial to address the correct treatment for advanced medullary thyroid cancer (MTC). Multi tyrosine kinase inhibitors (mTKIs) cabozantinib and vandetanib are good first line options, even vandetanib prescription is currently limited to RET mutated patients. Selective RET inhibitors such as pralsetinib could be a preferred upfront treatment in case of RET mutated MTC presenting common or gatekeeper RET mutations (e.g. M918T; V804L/M). Selpercatinib, otherwise, can be prescribed as the second line after disease progression to mTKIs. The best option for subsequent lines is to consider inclusion in clinical trials or alternatively other mTKIs such as sunitinib, sorafenib, lenvatinib, or pazopanib could be evaluated. New perspectives include next-generation RET inhibitors able to overcome resistance mechanisms responsible for disease progression to standard mTKIs and RET inhibitors, and immunotherapy for MTC presenting with high tumor mutational burden.

SUBMITTER: Lagana M

PROVIDER: S-EPMC10781862 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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The Evolving Treatment Landscape of Medullary Thyroid Cancer.

Laganà Marta M Cremaschi Valentina V Alberti Andrea A Vodopivec Kuri Danica M DM Cosentini Deborah D Berruti Alfredo A

Current treatment options in oncology 20231118 12

<h4>Opinion statement</h4>Genetic assessment is crucial to address the correct treatment for advanced medullary thyroid cancer (MTC). Multi tyrosine kinase inhibitors (mTKIs) cabozantinib and vandetanib are good first line options, even vandetanib prescription is currently limited to RET mutated patients. Selective RET inhibitors such as pralsetinib could be a preferred upfront treatment in case of RET mutated MTC presenting common or gatekeeper RET mutations (e.g. M918T; V804L/M). Selpercatinib ...[more]

PMID: 37979019

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Dataset Information

The Evolving Treatment Landscape of Medullary Thyroid Cancer.

Opinion statement

Publications

The Evolving Treatment Landscape of Medullary Thyroid Cancer.

Similar Datasets

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