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Scalable integrated two-dimensional Fourier-transform spectrometry.

ABSTRACT: Integrated spectrometers offer the advantages of small sizes and high portability, enabling new applications in industrial development and scientific research. Integrated Fourier-transform spectrometers (FTS) have the potential to realize a high signal-to-noise ratio but typically have a trade-off between the resolution and bandwidth. Here, we propose and demonstrate the concept of the two-dimensional FTS (2D-FTS) to circumvent the trade-off and improve scalability. The core idea is to utilize 2D Fourier transform instead of 1D Fourier transform to rebuild spectra. By combining a tunable FTS and a spatial heterodyne spectrometer, the interferogram becomes a 2D pattern with variations of heating power and arm lengths. All wavelengths are mapped to a cluster of spots in the 2D Fourier map beyond the free-spectral-range limit. At the Rayleigh criterion, the demonstrated resolution is 250 pm over a 200-nm bandwidth. The resolution can be enhanced to 125 pm using the computational method.

SUBMITTER: Xu H

PROVIDER: S-EPMC10781879 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Scalable integrated two-dimensional Fourier-transform spectrometry.

Xu Hongnan H Qin Yue Y Hu Gaolei G Tsang Hon Ki HK

Nature communications 20240110 1

Integrated spectrometers offer the advantages of small sizes and high portability, enabling new applications in industrial development and scientific research. Integrated Fourier-transform spectrometers (FTS) have the potential to realize a high signal-to-noise ratio but typically have a trade-off between the resolution and bandwidth. Here, we propose and demonstrate the concept of the two-dimensional FTS (2D-FTS) to circumvent the trade-off and improve scalability. The core idea is to utilize 2 ...[more]

PMID: 38200000

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Project description:Metabolomics is an interdisciplinary field that aims to study all metabolites < 1500 Da that are ubiquitously found within all organisms. Metabolomics is experiencing exponential growth and commonly relies on high-resolution mass spectrometry (HRMS). Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) is a form of HRMS that is particularly well suited for metabolomics research due to its exceptionally high resolution (105-106) and sensitivity with a mass accuracy in parts per billion (ppb). In this regard, FT-ICR-MS can provide valuable insights into the metabolomics analysis of complex biological systems due to unique capabilities such as the easy separation of isobaric and isomeric species, isotopic fine structure analysis, spatial resolution of metabolites in cells and tissues, and a high confidence (<1 ppm mass error) in metabolite identification. Alternatively, the large and complex data sets, long acquisition times, high cost, and limited access mainly through national mass spectrometry facilities may impede the routine adoption of FT-ICR-MS by metabolomics researchers. This review examines recent applications of FT-ICR-MS metabolomics in the search for clinical and non-human biomarkers; for the analysis of food, beverage, and environmental samples; and for the high-resolution imaging of tissues and other biological samples. We provide recent examples of metabolomics studies that highlight the advantages of FT-ICR-MS for the detailed and reliable characterization of the metabolome. Additionally, we offer some practical considerations for implementing FT-ICR-MS into a research program by providing a list of FT-ICR-MS facilities and by identifying different high-throughput interfaces, varieties of sample types, analysis methods (e.g., van Krevelen diagrams, Kendrick mass defect plot, etc.), and sample preparation and handling protocols used in FT-ICR-MS experiments. Overall, FT-ICR-MS holds great promise as a vital research tool for advancing metabolomics investigations.

Dataset Information

Scalable integrated two-dimensional Fourier-transform spectrometry.

Publications

Scalable integrated two-dimensional Fourier-transform spectrometry.

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