Ontology highlight
ABSTRACT:
SUBMITTER: Meyer CF
PROVIDER: S-EPMC10782853 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Meyer Claudio F CF Seath Ciaran P CP Knutson Steve D SD Lu Wenyun W Rabinowitz Joshua D JD MacMillan David W C DWC
Journal of the American Chemical Society 20221216 51
Sialylation, the addition of sialic acid to glycans, is a crucial post-translational modification of proteins, contributing to neurodevelopment, oncogenesis, and immune response. In cancer, sialylation is dramatically upregulated. Yet, the functional biochemical consequences of sialylation remain mysterious. Here, we establish a μMap proximity labeling platform that utilizes metabolically inserted azidosialic acid to introduce iridium-based photocatalysts on sialylated cell-surface glycoproteins ...[more]