Dataset Information

Comparative analysis of a rapid diagnostic test and scoring tools for ESBL detection in Enterobacterales bloodstream infections for optimizing antimicrobial therapy.

ABSTRACT:

Importance

Our study addresses a significant issue in the medical and scientific community-the delayed administration of appropriate antimicrobial treatments due to the time-consuming process of phenotypic susceptibility data collection in gram-negative bloodstream infections. Our research indicates that a multiplex PCR rapid diagnostic test (RDT) significantly outperformed two clinical scoring tools in predicting ceftriaxone susceptibility. Multiplex PCR also led to reduced instances of undertreatment with ceftriaxone and minimized overtreatment with carbapenems. Furthermore, multiplex PCR demonstrated high sensitivity and specificity in predicting ceftriaxone susceptibility. The results of our study underscore the potential RDTs to reduce the time to appropriate antimicrobial therapy, leading to improved patient outcomes and reduced healthcare costs.

SUBMITTER: Andrews SR

PROVIDER: S-EPMC10783129 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparative analysis of a rapid diagnostic test and scoring tools for ESBL detection in <i>Enterobacterales</i> bloodstream infections for optimizing antimicrobial therapy.

Andrews Sam R SR Timbrook Tristan T TT Fisher Mark A MA Tritle Brandon J BJ

Microbiology spectrum 20231213 1

<h4>Importance</h4>Our study addresses a significant issue in the medical and scientific community-the delayed administration of appropriate antimicrobial treatments due to the time-consuming process of phenotypic susceptibility data collection in gram-negative bloodstream infections. Our research indicates that a multiplex PCR rapid diagnostic test (RDT) significantly outperformed two clinical scoring tools in predicting ceftriaxone susceptibility. Multiplex PCR also led to reduced instances of ...[more]

PMID: 38088547

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