Ontology highlight
ABSTRACT:
SUBMITTER: Mann MK
PROVIDER: S-EPMC10785082 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Mann Mandeep K MK Wolf Esther E Silva Madhushika M Kwak Haejin Angela HA Wilson Brian B Bolotokova Albina A Wilson Derek J DJ Harding Rachel J RJ Schapira Matthieu M
ACS omega 20231215 1
Zinc-finger ubiquitin-binding domains (ZnF-UBDs) are noncatalytic domains mostly found in deubiquitylases (DUBs) such as USP3. They represent an underexplored opportunity for the development of deubiquitylase-targeting chimeras (DUBTACs) to pharmacologically induce the deubiquitylation of target proteins. We previously showed that ZnF-UBDs are ligandable domains. Here, a focused small molecule library screen against a panel of 11 ZnF-UBDs led to the identification of compound 59, a ligand engagi ...[more]