Ontology highlight
ABSTRACT:
SUBMITTER: Meyer SM
PROVIDER: S-EPMC10786349 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Meyer Samantha M SM Tanaka Toru T Zanon Patrick R A PRA Baisden Jared T JT Abegg Daniel D Yang Xueyi X Akahori Yoshihiro Y Alshakarchi Zainab Z Cameron Michael D MD Adibekian Alexander A Disney Matthew D MD
Journal of the American Chemical Society 20221107 46
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L to provide a compound that induced dimerization of RNase L, activating its ribonuclease activity. This compound was incorporated into the design of a next-generation RiboTAC that targeted the microRNA-21 (miR-21) precursor and alleviated a miR-21-as ...[more]