Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses.
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ABSTRACT:
SUBMITTER: Victoria C
PROVIDER: S-EPMC10788925 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses.
Victoria Catherine C Schulz Göran G Klöhn Mara M Weber Saskia S Holicki Cora M CM Brüggemann Yannick Y Becker Miriam M Gerold Gisa G Eiden Martin M Groschup Martin H MH Steinmann Eike E Kirschning Andreas A
Journal of medicinal chemistry 20231221 1
The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4', 6 and 8 was shown to have a significant effect on the antiviral activit ...[more]
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