Dataset Information

MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer.

ABSTRACT:

Objectives

To analyze multiparametric MRI (mpMRI) characteristics of patients with International Society of Urological Pathology (ISUP) grade group (GG) 4 or 5 prostate cancer (PC) and to correlate MRI parameters with the occurrence of biochemical recurrence (BCR) after radical prostatectomy (RPE).

Methods

In this single-center cohort study consecutive patients with mpMRI and ISUP GG 4 or 5 PC were retrospectively analyzed. Clinical, MR-guided biopsy, and diagnostic mpMRI parameter were assessed. A subcohort of patients with RPE and follow-up was analyzed separately. A univariate and multivariate analyses were performed to determine parameters that are associated to patients with BCR after RPE.

Results

145 patients (mean age 70y, median PSA 10.9 ng/ml) were analyzed. 99% had a PI-RADS classification of 4 or 5, 48% revealed MRI T3 stage, and median diameter of the MRI index lesion (IL) was 15 mm. IL showed a median ADC value of 668 ×10^-6 mm²/s and exhibited contrast enhancement in 94% of the cases. For patients with follow-up after RPE (n = 82; mean follow-up time 68 ± 27 m), MRI parameters were significantly different for contact length of the IL to the pseudocapsule (LCC), MRI T3 stage, and IL localization (p < 0.05). Higher PSAD and MRI T3 stage were independent parameters for the risk of BCR when incorporating clinical, biopsy, and MRI parameters.

Conclusion

ISUP GG 4 or 5 PC has distinctive characteristics on mpMRI and were detected on MRI in all cases. In addition, higher PSAD and MRI T3 stage were significant predictors for BCR after RPE.

SUBMITTER: Boschheidgen M

PROVIDER: S-EPMC10789849 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer.

Boschheidgen M M Schimmöller L L Kastl R R Drewes L R LR Jannusch K K Radke K L KL Kirchner J J Ullrich T T Niegisch G G Albers P P Antoch G G Radtke J P JP

Abdominal radiology (New York) 20231031 1

<h4>Objectives</h4>To analyze multiparametric MRI (mpMRI) characteristics of patients with International Society of Urological Pathology (ISUP) grade group (GG) 4 or 5 prostate cancer (PC) and to correlate MRI parameters with the occurrence of biochemical recurrence (BCR) after radical prostatectomy (RPE).<h4>Methods</h4>In this single-center cohort study consecutive patients with mpMRI and ISUP GG 4 or 5 PC were retrospectively analyzed. Clinical, MR-guided biopsy, and diagnostic mpMRI paramete ...[more]

PMID: 37906272

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Dataset Information

MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer.

Objectives

Methods

Results

Conclusion

Publications

MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer.

Similar Datasets

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