Dataset Information
Bacteriophage infection and killing of intracellular Mycobacterium abscessus.
Ontology highlight
ABSTRACT: Importance
As we rapidly approach a post-antibiotic era, bacteriophage (phage) therapy may offer a solution for treating drug-resistant bacteria. Mycobacterium abscessus is an emerging, multidrug-resistant pathogen that causes disease in people with cystic fibrosis, chronic obstructive pulmonary disease, and other underlying lung diseases. M. abscessus can survive inside host cells, a niche that can limit access to antibiotics. As current treatment options for M. abscessus infections often fail, there is an urgent need for alternative therapies. Phage therapy is being used to treat M. abscessus infections as an option of last resort. However, little is known about the ability of phages to kill bacteria in the host environment and specifically in an intracellular environment. Here, we demonstrate the ability of phages to enter mammalian cells and to infect and kill intracellular M. abscessus. These findings support the use of phages to treat intracellular bacterial pathogens.
SUBMITTER: Schmalstig AA
PROVIDER: S-EPMC10790704 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Bacteriophage infection and killing of intracellular <i>Mycobacterium abscessus</i>.
mBio 20231207 1
<h4>Importance</h4>As we rapidly approach a post-antibiotic era, bacteriophage (phage) therapy may offer a solution for treating drug-resistant bacteria. <i>Mycobacterium abscessus</i> is an emerging, multidrug-resistant pathogen that causes disease in people with cystic fibrosis, chronic obstructive pulmonary disease, and other underlying lung diseases. <i>M. abscessus</i> can survive inside host cells, a niche that can limit access to antibiotics. As current treatment options for <i>M. abscess ...[more]