Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC10790813 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation.
Zhang Zhenjiang Z King Michael R MR
Nanoscale advances 20231229 2
Phase-separated liposomes were used to formulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a protein that selectively kills cancer cells while sparing most healthy ones. By controlling the average number of TRAIL molecules per liposome, we demonstrate the ability to tune the formation of TRAIL clusters and their resulting apoptotic activity. ...[more]
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