Dataset Information

Cell-free DNA levels associate with COPD exacerbations and mortality.

ABSTRACT:

The question addressed by the study

Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and released by cigarette smoke exposure, plasma cell-free mitochondrial and nuclear DNA (cf-mtDNA and cf-nDNA) levels could potentially integrate disease physiology and clinical phenotypes in COPD. This study aimed to determine whether plasma cf-mtDNA and cf-nDNA levels are associated with COPD disease severity, exacerbations, and mortality risk.

Materials and methods

We quantified mtDNA and nDNA copy numbers in plasma from participants enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE, n = 2,702) study and determined associations with relevant clinical parameters.

Results

Of the 2,128 participants with COPD, 65% were male and the median age was 64 (interquartile range, 59-69) years. During the baseline visit, cf-mtDNA levels positively correlated with future exacerbation rates in subjects with mild/moderate and severe disease (Global Initiative for Obstructive Lung Disease [GOLD] I/II and III, respectively) or with high eosinophil count (≥ 300). cf-nDNA positively associated with an increased mortality risk (hazard ratio, 1.33 [95% confidence interval, 1.01-1.74] per each natural log of cf-nDNA copy number). Additional analysis revealed that individuals with low cf-mtDNA and high cf-nDNA abundance further increased the mortality risk (hazard ratio, 1.62 [95% confidence interval, 1.16-2.25] per each natural log of cf-nDNA copy number).

Answer to the question

Plasma cf-mtDNA and cf-nDNA, when integrated into quantitative clinical measurements, may aid in improving COPD severity and progression assessment.

SUBMITTER: Ware SA

PROVIDER: S-EPMC10797855 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Cell-free DNA levels associate with COPD exacerbations and mortality.

Ware Sarah A SA Kliment Corrine R CR Giordano Luca L Redding Kevin M KM Rumsey William L WL Bates Stewart S Zhang Yingze Y Sciurba Frank C FC Nouraie S Mehdi SM Kaufman Brett A BA

Respiratory research 20240118 1

<h4>The question addressed by the study</h4>Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and released by cigarette smoke exposure, plasma cell-free mitochondrial and nuclear DNA (cf-mtDNA and cf-nDNA) levels could potentially integrate disease physiology and clinical phenotypes in COPD. This study aimed to determine whether plasma cf-mtDNA and c ...[more]

PMID: 38238743

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Dataset Information

Cell-free DNA levels associate with COPD exacerbations and mortality.

The question addressed by the study

Materials and methods

Results

Answer to the question

Publications

Cell-free DNA levels associate with COPD exacerbations and mortality.

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