Ontology highlight
ABSTRACT:
SUBMITTER: Cosgrove BD
PROVIDER: S-EPMC10802421 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20240110
Epigenetic control of cellular transcription and phenotype is influenced by changes in the cellular microenvironment, yet how mechanical cues from these microenvironments precisely influence epigenetic state to regulate transcription remains largely unmapped. Here, we combine genome-wide epigenome profiling, epigenome editing, and phenotypic and single-cell RNA-seq CRISPR screening to identify a new class of genomic enhancers that responds to the mechanical microenvironment. These 'mechanoenhanc ...[more]