Ontology highlight
ABSTRACT:
SUBMITTER: McCallum M
PROVIDER: S-EPMC10802434 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20240109
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor tropism remain elusive. Here, we designed an active human TMPRSS2 construct enabling high-yield recombinant production in human cells of this key therapeutic target. We determined a cryo-electron microscopy structure of the HKU1 RBD bound to human TMPRSS2 provi ...[more]