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Molecular events in neuroendocrine prostate cancer development.

ABSTRACT: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises de novo only rarely; the disease predominantly develops from adenocarcinoma in response to drug-induced androgen receptor signalling inhibition, although the mechanisms behind this transdifferentiation are a subject of debate. The survival of patients with NEPC is poor, and few effective treatment options are available. To improve clinical outcomes, understanding of the biology and molecular mechanisms regulating NEPC development is crucial. Various NEPC molecular drivers make temporal contributions during NEPC development, and despite the limited treatment options available, several novel targeted therapeutics are currently under research.

SUBMITTER: Wang Y

PROVIDER: S-EPMC10802813 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Molecular events in neuroendocrine prostate cancer development.

Wang Yong Y Wang Yu Y Ci Xinpei X Choi Stephen Y C SYC Crea Francesco F Lin Dong D Wang Yuzhuo Y

Nature reviews. Urology 20210721 10

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises de novo only rarely; the disease predominantly develops from adenocarcinoma in response to drug-induced androgen receptor signalling inhibition, although the mechanisms behind this transdifferentiation are a subject of debate. The survival of patients with NEPC is poor, and few effective treatment options are available. To improve clinical outcomes, understanding of the biology and molecular mechanisms regu ...[more]

PMID: 34290447

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