Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis.

ABSTRACT: Methanogens are essential for the complete remineralization of organic matter in anoxic environments. Most cultured methanogens are hydrogenotrophic, using H₂ as an electron donor to reduce CO₂ to CH₄, but in the absence of H₂ many can also use formate. Formate dehydrogenase (Fdh) is essential for formate oxidation, where it transfers electrons for the reduction of coenzyme F₄₂₀ or to a flavin-based electron bifurcating reaction catalyzed by heterodisulfide reductase (Hdr), the terminal reaction of methanogenesis. Furthermore, methanogens that use formate encode at least two isoforms of Fdh in their genomes, but how these different isoforms participate in methanogenesis is unknown. Using Methanococcus maripaludis, we undertook a bioche

SUBMITTER: Abdul Halim MF 

PROVIDER: S-EPMC10805699 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature