Ontology highlight
ABSTRACT:
SUBMITTER: Sepp M
PROVIDER: S-EPMC10808058 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Sepp Mari M Leiss Kevin K Murat Florent F Okonechnikov Konstantin K Joshi Piyush P Leushkin Evgeny E Spänig Lisa L Mbengue Noe N Schneider Céline C Schmidt Julia J Trost Nils N Schauer Maria M Khaitovich Philipp P Lisgo Steven S Palkovits Miklós M Giere Peter P Kutscher Lena M LM Anders Simon S Cardoso-Moreira Margarida M Sarropoulos Ioannis I Pfister Stefan M SM Kaessmann Henrik H
Nature 20231129 7996
The expansion of the neocortex, a hallmark of mammalian evolution<sup>1,2</sup>, was accompanied by an increase in cerebellar neuron numbers<sup>3</sup>. However, little is known about the evolution of the cellular programmes underlying the development of the cerebellum in mammals. In this study we generated single-nucleus RNA-sequencing data for around 400,000 cells to trace the development of the cerebellum from early neurogenesis to adulthood in human, mouse and the marsupial opossum. We esta ...[more]