Ontology highlight
ABSTRACT:
SUBMITTER: Garsevanyan S
PROVIDER: S-EPMC10812414 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Garsevanyan Sona S Barlow Miriam M
Antibiotics (Basel, Switzerland) 20231231 1
<i>Klebsiella pneumoniae</i> carbapenemase KPC is an important resistance gene that has disseminated globally in response to carbapenem use. It is now being implicated as a resistance determinant in Ceftazidime Avibactam (CAZ-AVI) resistance. Given that CAZ-AVI is a last-resort antibiotic, it is critical to understand how resistance to this drug is evolving. In particular, we were interested in determining the evolutionary response of KPC to CAZ-AVI consumption. Through phylogenetic reconstructi ...[more]