CRISPRing KRAS: A Winding Road with a Bright Future in Basic and Translational Cancer Research.
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ABSTRACT:
SUBMITTER: Gong X
PROVIDER: S-EPMC10814442 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
CRISPRing <i>KRAS</i>: A Winding Road with a Bright Future in Basic and Translational Cancer Research.
Gong Xian X Du Jianting J Peng Ren-Wang RW Chen Chun C Yang Zhang Z
Cancers 20240122 2
Once considered "undruggable" due to the strong affinity of RAS proteins for GTP and the structural lack of a hydrophobic "pocket" for drug binding, the development of proprietary therapies for KRAS-mutant tumors has long been a challenging area of research. CRISPR technology, the most successful gene-editing tool to date, is increasingly being utilized in cancer research. Here, we provide a comprehensive review of the application of the CRISPR system in basic and translational research in KRAS- ...[more]
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