Ontology highlight
ABSTRACT:
SUBMITTER: Nakamoto K
PROVIDER: S-EPMC10814450 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Nakamoto Keitaro K Kikuhara Sota S Fujimori Hiroaki H Saraswat Barkha B Gao Zhongming Z Vadi Velu Ankitha A Zhang Zongxiang Z Tong Ying Y Imamichi Shoji S Nozaki Tadashige T Murakami Yasufumi Y Masutani Mitsuko M
Current issues in molecular biology 20240102 1
Developing strategies for the radiosensitization of cancer cells by the inhibition of genes, which harbor low toxicity to normal cells, will be useful for improving cancer radiotherapy. Here, we focused on a β-site of amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1; β-secretase, memapsin-2). By functional inhibition of this peptidase by siRNA, it has also recently been shown that the DNA strand break marker, γH2AX foci, increased, suggesting its involvement in DNA damage response. To in ...[more]