Ontology highlight
ABSTRACT:
SUBMITTER: Skalniak A
PROVIDER: S-EPMC10816043 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Skalniak Anna A Trofimiuk-Müldner Małgorzata M Surmiak Marcin M Totoń-Żurańska Justyna J Jabrocka-Hybel Agata A Hubalewska-Dydejczyk Alicja A
International journal of molecular sciences 20240115 2
Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by tumors in multiple organs. Although being a dominantly inherited monogenic disease, disease phenotypes are unpredictable and differ even among members of the same family. There is growing evidence for the role of modifier genes in the alteration of the course of this disease. However, genome-wide screening data are still lacking. In our study, we addressed the different outcomes of the disease, focusing on pituitary and ad ...[more]