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Manganese and IL-12 treatment alters the ovarian tumor microenvironment.

ABSTRACT: Metal immunotherapy is a novel adjuvant immunotherapy. Mn²⁺ can activate STING-a type I IFN response protein-that promotes innate immunity and increases anti-tumor activity by promoting macrophage phagocytosis. IL-12, a cytokine that increases the antigen-presenting ability to promote effector T-cell activation, has potent antitumor activity, albeit with severe adverse effects. In this study, we observed that the combination of Mn²⁺ and IL-12 has a better antitumor effect and possibly reflects a better safety profile, providing a novel approach and theoretical basis for safe and rapid cancer treatment.

SUBMITTER: Xu Y

PROVIDER: S-EPMC10817382 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Manganese and IL-12 treatment alters the ovarian tumor microenvironment.

Xu Yan Y Huang Xin X Nie Xiao-Cui XC Liu Yan-Song YS Zhou Yang Y Niu Ju-Min JM

Aging 20240103 1

Metal immunotherapy is a novel adjuvant immunotherapy. Mn2+ can activate STING-a type I IFN response protein-that promotes innate immunity and increases anti-tumor activity by promoting macrophage phagocytosis. IL-12, a cytokine that increases the antigen-presenting ability to promote effector T-cell activation, has potent antitumor activity, albeit with severe adverse effects. In this study, we observed that the combination of Mn2+ and IL-12 has a better antitumor effect a ...[more]

PMID: 38175694

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