Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC10818060 | biostudies-literature | 2024 May
REPOSITORIES: biostudies-literature
Xu Dongdong D Hu Jun J Mei Jiawei J Zhou Jun J Wang Zhengxi Z Zhang Xudong X Liu Quan Q Su Zheng Z Zhu Wanbo W Liu Hongjian H Zhu Chen C
Bioactive materials 20240124
Repetitive implant-related infections (IRIs) are devastating complications in orthopedic surgery, threatening implant survival and even the life of the host. Biofilms conceal bacterial-associated antigens (BAAs) and result in a "cold tumor"-like immune silent microenvironment, allowing the persistence of IRIs. To address this challenge, an iron-based covalent organic framed nanoadjuvant doped with curcumin and platinum (CFCP) was designed in the present study to achieve efficient treatment of IR ...[more]