Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC10822848 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Liu Yi Y Ma Jichun J DesJarlais Renee L RL Hagan Rebecca R Rech Jason J Liu Changlu C Miller Robyn R Schoellerman Jeffrey J Luo Jinquan J Letavic Michael M Grasberger Bruce B Maher Michael P MP
Scientific reports 20240128 1
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent cations are not well understood. Previously, we identified two small molecules that bind to ASIC1a at a novel site in the acidic pocket and modulate ASIC1 gating in a manner broadly resembling divalent cations, raising the possibility that these small ...[more]