Dataset Information

Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).

ABSTRACT:

Background

Klotho is an anti-aging protein that has multiple functions and may play a key role in the pathogenesis and progression of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Fractional Exhaled Nitric Oxide (FeNO) is a non-invasive and novel biomarker that has the advantages of being simple, fast and reproducible. It can effectively assess the degree of airway inflammation in diseases such as asthma and COPD. Despite these insights, the relationship between serum Klotho levels and FeNO has not been explored yet.

Methods

Leveraging data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2012, we investigated the correlation between FeNO and serum Klotho levels. This association was scrutinized both as continuous variables and within quartile distributions, utilizing the Kruskal-Wallis H test. The correlation between the two variables was assessed through Spearman rank analysis. Employing survey weight-adjusted linear regression models, we gauged the strength of these associations.

Results

This study included 6,527 participants with a median FeNO level of 14.5 parts per billion (ppb). We found that FeNO levels varied significantly across different quartiles of Klotho protein (H = 7.985, P = 0.046). We also found a significant positive correlation between serum Klotho levels and FeNO levels in the whole population (Spearman's rho = 0.029, P = 0.019). This correlation remained significant after adjusting for covariates such as age, gender, lung function, smoking status, alcohol use, BMI, cardiovascular disease (including hypertension, heart failure, coronary heart disease, and myocardial infarction), diabetes, inflammatory markers, serum vitamin D level and BUN (P < 0.05 for all). Furthermore, this correlation was stronger at the high (K3) and super high (K4) levels of Klotho than at the low (K1) and medium (K2) levels (β = 1.979 ppb and β = 1.993 ppb for K3 and K4 vs. K1, respectively; 95% CI: 0.497 ~ 2.953 and 95% CI: 0.129 ~ 2.827, respectively; P = 0.007 and P = 0.032, respectively). The β coefficient for serum Klotho was 0.002 ppb/pg/ml.

Conclusions

Our study illuminates a positive correlation between serum Klotho levels and FeNO. Further study is needed to verify the causality of this association and elucidate the underlying mechanisms.

SUBMITTER: Mao H

PROVIDER: S-EPMC10823643 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).

Mao Haiyan H Xie Zhenye Z Huang Shanshan S Shen Xingkai X Jin Shaofeng S Lin Tong T Yang Zhouxin Z

BMC pulmonary medicine 20240129 1

<h4>Background</h4>Klotho is an anti-aging protein that has multiple functions and may play a key role in the pathogenesis and progression of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Fractional Exhaled Nitric Oxide (FeNO) is a non-invasive and novel biomarker that has the advantages of being simple, fast and reproducible. It can effectively assess the degree of airway inflammation in diseases such as asthma and COPD. Despite these insights, the relations ...[more]

PMID: 38287280

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Project description:BackgroundOsteoarthritis (OA) is a degenerative joint disease prevalent in the elderly. Currently, the relationship between the senescence inhibitor Klotho and OA remains unclear. This study investigated the relationship between serum soluble Klotho (S-Klotho) and OA.MethodsThis cross-sectional study was based on the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Three multifactorial logistic regression models were constructed to assess the association between serum Klotho and OA. Restricted cubic spline (RCS) curves were further used to assess whether there was a nonlinear relationship between serum Klotho and OA. Finally, stratified analyses and interaction tests were used to evaluate the association's stability. To further investigate the relationship between serum Klotho and OA, we recruited 107 patients for analysis at the First Affiliated Hospital of Guangxi Medical University.ResultsThe final 8,918 participants included in this study comprised 50.55% females and 49.45% males, with 18.10% of participants suffering from OA and a mean S-Klotho level of 846.41 (5.61) pg/ml. All three logistic regression models observed a negative association between continuous S-Klotho and OA risk. When S-Klotho was categorized into tertiles, the fully adjusted model showed that participants in the third tertile had a 17% lower risk of OA than those in the first tertile (OR = 0.83, 95% CI: 0.70, 0.99, P = 0.035). The RCS curves showed a linear negative association between S-Klotho and the incidence of OA (P for overall = 0.025; P for non-linearity = 0.667). Further subgroup analyses and interaction tests suggested that the negative association between S-Klotho and OA remained stable in different conditions. Research conducted in China has shown that the negative correlation between serum Klotho levels and the prevalence of OA remains evident among Chinese individuals (OR: 0.77, 95% CI: 0.66, 0.90, P<0.001).ConclusionOur study suggests that elevated levels of the senescence inhibitor S-Klotho may be a potential protective factor for OA, which may provide new insights into the diagnosis and treatment of OA.

Project description:This study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain the potential of serum α-Klotho levels as a predictive biomarker for hyperlipidemia. The research employed data from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2016. Weighted logistic regression analyses were employed to investigate the association between serum α-Klotho levels and hyperlipidemia. Restricted cubic spline (RCS) analyses were executed for males and females to scrutinize the non-linear correlation between α-Klotho levels and hyperlipidemia. Subsequently, piecewise logistic regression analysis was carried out based on the RCS findings. In females, the levels of α-Klotho were notably lower in those with hyperlipidemia in comparison to those without this condition (P < 0.05), No significant variation was demonstrated in α-Klotho levels between males with and without hyperlipidemia (P > 0.05). The participants were stratified by sex and subjected to analysis by logistic regression model. When α-Klotho was log2-transformed, it was significantly negatively associated with the risk of hyperlipidemia in females, even after adjusting for all of the covariates (OR 0.45, 95% CI 0.24-0.82), which was not observed in males (OR 1.14, 95% CI 0.63-2.06). The same results were observed in the third tertile of α-Klotho. Moreover, RCS analysis suggested a nonlinear correlation between serum α-Klotho levels and hyperlipidemia in females (P < 0.01). The inflection point of α-Klotho was found to be 1106.87 pg/mL. The piecewise logistic regression model revealed that when α-Klotho levels exceeded 1106.87 pg/mL, the link between α-Klotho and hyperlipidemia was no longer significant (P > 0.05). This investigation highlights the sex-based variation in the link between serum α-Klotho levels and hyperlipidemia. In females, α-Klotho exhibited negative association with hyperlipidemia, displaying a saturation effect. Serum α-Klotho emerges as a promising biological marker for the risk of hyperlipidemia among females.

Dataset Information

Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).

Background

Methods

Results

Conclusions

Publications

Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).

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