Ontology highlight
ABSTRACT:
SUBMITTER: Calcedo R
PROVIDER: S-EPMC10826927 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Calcedo Roberto R Vandenberghe Luk H LH Gao Guangping G Lin Jianping J Wilson James M JM
The Journal of infectious diseases 20090201 3
Recombinant adeno-associated viruses (AAVs) have unique gene-transfer properties that speak to their potential as carriers for gene therapy or vaccine applications. However, the presence of neutralizing antibodies to AAV as a result of previous exposure can significantly limit effective gene transfer. In this study, we obtained 888 human serum samples from healthy volunteers in 10 countries around the world. Samples were assayed for neutralizing antibodies to AAV1, AAV2, AAV7, and AAV8, as well ...[more]