Ontology highlight
ABSTRACT:
SUBMITTER: Ji G
PROVIDER: S-EPMC1082806 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Journal of bacteriology 20050501 9
The agr system is a global regulator of accessory functions in staphylococci, including genes encoding exoproteins involved in virulence. The agr locus contains a two-component signal transduction module that is activated by an autoinducing peptide (AIP) encoded within the agr locus and is conserved throughout the genus. The AIP has an unusual partially cyclic structure that is essential for function and that, in all but one case, involves an internal thiolactone bond between a conserved cystein ...[more]