Ontology highlight
ABSTRACT:
SUBMITTER: Price-Carter M
PROVIDER: S-EPMC1082818 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Price-Carter Marian M Fazzio Thomas G TG Vallbona Ester Ibañez EI Roth John R JR
Journal of bacteriology 20050501 9
Mutants of Salmonella enterica lacking polyphosphate kinase (ppk) grow poorly in the presence of the weak organic acids acetate, propionate, and benzoate. This sensitivity is corrected by methionine and seems to result from destabilization of MetA (homoserine transsuccinylase), the first enzyme in methionine biosynthesis. The MetA protein is known to be sensitive to thermal inactivation, and ppk mutants are more sensitive to heat-induced methionine auxotrophy. Peroxide increases the sensitivity ...[more]