Ontology highlight
ABSTRACT:
SUBMITTER: Fluckiger U
PROVIDER: S-EPMC108284 | biostudies-literature | 1998 Jun
REPOSITORIES: biostudies-literature
Fluckiger U U Wolz C C Cheung A L AL
Infection and immunity 19980601 6
Coagulase-negative staphylococci are common nosocomial pathogens. A regulatory element, designated sar, partially controls exoprotein synthesis in coagulase-positive Staphylococcus aureus by modulating the expression of another regulatory locus, called agr. We report here the cloning of a sar homolog in S. epidermidis. The major open reading frame within sar in S. epidermidis is highly homologous (84%) to the S. aureus SarA protein. Primer extension studies revealed three sar transcripts (0.64, ...[more]