Ontology highlight
ABSTRACT:
SUBMITTER: Cokol M
PROVIDER: S-EPMC1083765 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential NLSs. This final set matched in 43% of all known nuclear proteins and in no known non-nuclear protein. We estimated that >17% of all eukaryotic proteins may be imported into the nuc ...[more]