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A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.

ABSTRACT: The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.

SUBMITTER: Suzuki N

PROVIDER: S-EPMC1083904 | biostudies-literature | 2001 Jun

REPOSITORIES: biostudies-literature

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A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.

Suzuki N N Buechner M M Nishiwaki K K Hall D H DH Nakanishi H H Takai Y Y Hisamoto N N Matsumoto K K

EMBO reports 20010601 6

The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for f ...[more]

PMID: 11415987

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