Ontology highlight
ABSTRACT:
SUBMITTER: Pereira PJ
PROVIDER: S-EPMC1083928 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Pereira Pedro José Barbosa PJ Vega M Cristina MC González-Rey Elena E Fernández-Carazo Rafael R Macedo-Ribeiro Sandra S Gomis-Rüth F Xavier FX González Antonio A Coll Miquel M
EMBO reports 20011219 1
The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion. We have determined the three-dimensional crystal structure of TcMIP at 1.7 A resolution. The monomeric protein displays a peptidyl-prolyl cis-trans isomerase (PPIase) core, encompassing the characteristic rotamase hydrophobic active site, thus explaining the strong inhibition of TcMIP by ...[more]