Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC10839686 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Wang Xiaoshuang X Zhou Yan Y Wu Zhongen Z Xie Cao C Xu Weiqi W Zhou Qingtong Q Yang Dehua D Zhu Di D Wang Ming-Wei MW Wang Lu L
iScience 20240112 2
Liver metastasis (LM) is the primary cause of cancer-related mortality in late-stage breast cancer (BC) patients. Here we report an in-depth analysis of the transcriptional landscape of LM of 11 patients with secondary hepatic carcinoma at single-cell resolution. Our study reveals that terminally exhausted CD4<sup>+</sup> and dysfunctional CD8<sup>+</sup> T cells were enriched in LM along with low antigen presentation. We also found that macrophages were associated with the tumor infiltrating CD ...[more]