Ontology highlight
ABSTRACT:
SUBMITTER: Karetsou Z
PROVIDER: S-EPMC1084059 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Karetsou Zoe Z Kretsovali Adroniki A Murphy Carol C Tsolas Orestes O Papamarcaki Thomais T
EMBO reports 20020315 4
Prothymosin alpha (ProTalpha) is a histone H1-binding protein localized in sites of active transcription in the nucleus. We report here that ProTalpha physically interacts with the CREB-binding protein (CBP), which is a versatile transcription co-activator. Confocal laser scanning microscopy reveals that ProTalpha partially colocalizes with CBP in discrete subnuclear domains. Using transient transfections, we show that ProTalpha synergizes with CBP and stimulates AP1- and NF-kappaB-dependent tra ...[more]