Ontology highlight
ABSTRACT:
SUBMITTER: Fabbrizio E
PROVIDER: S-EPMC1084190 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Fabbrizio Eric E El Messaoudi Selma S Polanowska Jolanta J Paul Conception C Cook Jeffry R JR Lee Jin-Hyung JH Negre Vincent V Rousset Mathieu M Pestka Sidney S Le Cam Alphonse A Sardet Claude C
EMBO reports 20020701 7
We have identified previously a repressor element in the transcription start site region of the cyclin E1 promoter that periodically associates with an atypical, high molecular weight E2F complex, termed CERC. Purification of native CERC reveals the presence of the type II arginine methyltransferase PRMT5, which can mono- or symetrically dimethylate arginine residues in proteins. Chromatin immunoprecipitations (ChIPs) show that PRMT5 is associated specifically with the transcription start site r ...[more]