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Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2.

ABSTRACT: Classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2) are two of the most devastating and economically significant pathogens affecting pig populations worldwide. Administration of a combination of vaccines against swine pathogens has been demonstrated to be as efficacious as the administration of single vaccines. In this study, we developed and tested a novel bivalent subunit vaccine against CSFV and PCV2. The safety and efficacy of this vaccine were demonstrated in mice and specific pathogen-free (SPF) piglets. In addition to investigating the serological responses after immunization, challenge studies with both viruses were also conducted. The results showed that this CSFV/PCV2 bivalent vaccine elicited a high level of neutralizing antibodies against both viruses and provided protection in challenge studies. In conclusion, the CSFV/PCV2 bivalent vaccine is safe and effective against CSFV or PCV2 challenge.

SUBMITTER: Chen YS 

PROVIDER: S-EPMC10844208 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2.

Chen Yu-San YS   Lee Chang-Ye CY   Wu Chi-Chien CC   Kao Pei-Lun PL   Chen Tai-An TA   Huang Yahui Y   Chung Wen-Bin WB   Kuo Tsun-Yung TY   Chen Charles C  

Scientific reports 20240206 1

Classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2) are two of the most devastating and economically significant pathogens affecting pig populations worldwide. Administration of a combination of vaccines against swine pathogens has been demonstrated to be as efficacious as the administration of single vaccines. In this study, we developed and tested a novel bivalent subunit vaccine against CSFV and PCV2. The safety and efficacy of this vaccine were demonstrated in mice and sp  ...[more]

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