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Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis.


ABSTRACT: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the absolute number and/or enhancing the function of Tregs are effective strategies for treating RA. This article reviews the studies on the mechanisms and targeted therapies related to Tregs in RA, with a view to provide better ideas for the treatment of RA.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10844451 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis.

Zhang Jiaqian J   Liu Hongjiang H   Chen Yuehong Y   Liu Huan H   Zhang Shengxiao S   Yin Geng G   Xie Qibing Q  

Frontiers in immunology 20240123


Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the a  ...[more]

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