Ontology highlight
ABSTRACT:
SUBMITTER: Huesca M
PROVIDER: S-EPMC108486 | biostudies-literature | 1998 Sep
REPOSITORIES: biostudies-literature
Huesca M M Goodwin A A Bhagwansingh A A Hoffman P P Lingwood C A CA
Infection and immunity 19980901 9
The in vitro glycolipid binding specificity of the gastric pathogen Helicobacter pylori is altered to include sulfated glycolipids (sulfatides) following brief exposure of the organism to acid pH typical of the stomach. This change is prevented by anti-hsp70 antibodies, suggesting that hsp70 may be a stress-induced surface adhesin, mediating sulfatide recognition. To facilitate investigation of the role of hsp70 in attachment, we have cloned and sequenced the H. pylori hsp70 gene (dnaK). The hsp ...[more]