Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics.
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ABSTRACT:
SUBMITTER: Shin E
PROVIDER: S-EPMC10848756 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics.
Shin Eunjeong E Zhang Yongzhen Y Zhou Jieqiang J Lang Yinzhi Y Sayed Alaa R M ARM Werkman Carolin C Jiao Yuanyuan Y Kumaraswamy Monika M Bulman Zackery P ZP Luna Brian M BM Bulitta Jürgen B JB
Antimicrobial agents and chemotherapy 20240103 2
Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak co ...[more]
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