Ontology highlight
ABSTRACT:
SUBMITTER: Watson JA
PROVIDER: S-EPMC10849674 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Watson James A JA Commons Robert J RJ Tarning Joel J Simpson Julie A JA Llanos Cuentas Alejandro A Lacerda Marcus V G MVG Green Justin A JA Koh Gavin C K W GCKW Chu Cindy S CS Nosten François H FH Price Richard N RN Day Nicholas P J NPJ White Nicholas J NJ
eLife 20240207
In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti-relapse efficacy in tropical vivax malaria. We concluded that the currently recommended dose of tafenoquine (300 mg in adults, average dose of 5 mg/kg) is insufficient for cure in all adults, and a 50% increase to 450 mg (7.5 mg/kg) would halve the ...[more]