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Measuring excitation-inhibition balance through spectral components of local field potentials.

ABSTRACT: The balance between excitation and inhibition is critical to brain functioning, and dysregulation of this balance is a hallmark of numerous psychiatric conditions. Measuring this excitation-inhibition (E:I) balance in vivo has remained difficult, but theoretical models have proposed that characteristics of local field potentials (LFP) may provide an accurate proxy. To establish a conclusive link between LFP and E:I balance, we recorded single units and LFP from the prefrontal cortex (mPFC) of rats during decision making. Dynamic measures of synaptic coupling strength facilitated direct quantification of E:I balance and revealed a strong inverse relationship to broadband spectral power of LFP. These results provide a critical link between LFP and underlying network properties, opening the door for non-invasive recordings to measure E:I balance in clinical settings.

SUBMITTER: Diehl GW

PROVIDER: S-EPMC10849740 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Measuring excitation-inhibition balance through spectral components of local field potentials.

Diehl Geoffrey W GW Redish A David AD

bioRxiv : the preprint server for biology 20240124

The balance between excitation and inhibition is critical to brain functioning, and dysregulation of this balance is a hallmark of numerous psychiatric conditions. Measuring this excitation-inhibition (E:I) balance <i>in vivo</i> has remained difficult, but theoretical models have proposed that characteristics of local field potentials (LFP) may provide an accurate proxy. To establish a conclusive link between LFP and E:I balance, we recorded single units and LFP from the prefrontal cortex (mPFC ...[more]

PMID: 38328057

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Dataset Information

Measuring excitation-inhibition balance through spectral components of local field potentials.

Publications

Measuring excitation-inhibition balance through spectral components of local field potentials.

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