Targeted Inhibition of CYP11A1 in Castration-Resistant Prostate Cancer.
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ABSTRACT:
SUBMITTER: Fizazi K
PROVIDER: S-EPMC10852404 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Targeted Inhibition of CYP11A1 in Castration-Resistant Prostate Cancer.
Fizazi Karim K Bernard-Tessier Alice A Roubaud Guilhem G Utriainen Tapio T Barthélémy Philippe P Fléchon Aude A van der Voet Johannes J Gravis Gwenaëlle G Ratta Raffaele R Jones Robert R Parikh Omi O Tanner Minna M Antonarakis Emmanuel S ES Baldini Capucine C Peters Niamh N Garratt Chris C Ikonen Tarja T Pohjanjousi Pasi P Joensuu Heikki H Cook Natalie N
NEJM evidence 20231226 1
BACKGROUND: Prostate cancer is regulated by steroid hormones, even in castration-resistant disease. ODM-208, a novel inhibitor of cytochrome P450 11A1 (which catalyzes the first step of steroid-hormone biosynthesis), was investigated in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC). METHODS: CYPIDES is a first-in-human phase 1 (3 + 3 design) and phase 2 study. We administered ODM-208 twice daily with glucocorticoid/mineralocorticoid replacement and ongo ...[more]
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