Dataset Information

Occupational hypersensitivity pneumonia.

ABSTRACT: Hypersensitivity pneumonitis (HP) is an immunological lung disease that affects individuals who are sensitive and susceptible to occupational and environmental exposures. While clinical and radiological findings may resemble other interstitial lung diseases, identifying the causative agents can aid in the differential diagnosis. However, this can be challenging and may result in delayed diagnosis and poor prognosis. A gold standard test for diagnosis is currently unavailable, and therefore, a multidisciplinary approach involving a clinician, radiologist, and pathologist is necessary. Avoiding exposure is the first step in treatment, with immunosuppressive therapeutics also being used. Antifibrotic agents show promise for future treatment approaches. Despite recent advancements in data and guidelines, knowledge about managing occupational HP remains limited. This review provides a summary of the epidemiological, clinical, and radiological findings, as well as diagnostic and treatment principles of occupational HP based on current literature.

SUBMITTER: Akkale T

PROVIDER: S-EPMC10854060 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Occupational hypersensitivity pneumonia.

Akkale Tuğba T Sarı Gülden G Şimşek Ceprail C

Tuberkuloz ve toraks 20230301 1

Hypersensitivity pneumonitis (HP) is an immunological lung disease that affects individuals who are sensitive and susceptible to occupational and environmental exposures. While clinical and radiological findings may resemble other interstitial lung diseases, identifying the causative agents can aid in the differential diagnosis. However, this can be challenging and may result in delayed diagnosis and poor prognosis. A gold standard test for diagnosis is currently unavailable, and therefore, a mu ...[more]

PMID: 36912413

Similar Datasets

Project description:Work-related stress in police officers has been recognized as a risk factor for mental and physical illness, compromising work performance and public safety. While genetic, individual and environmental factors may contribute to stress, basic pathophysiological mechanisms are still not completely understood. Previous studies have shown the potential of microRNAs (miRNAs) as biomarkers and/or mediator for stress responses. In this study, we aimed at identifying possible dysregulation of salivary miRNAs associated with work-related stress in police officers. The study was conducted in a cohort composed of police officers in service at the mobile unit of Genoa in 2009, whose response to occupational stress has been continuously monitored since 2009 using the Demand-Control and the Effort-Reward Imbalance models. 113 male police officers in service in 2022 were recruited and divided in three groups according to their response to stress (low, intermediate and high stress response). miRNAs were extracted from saliva samples and analyzed by small RNA sequencing followed by an integrated bioinformatics/biostatistics analysis. The high stress response group was characterized by 18 differentially expressed miRNAs compared with the low stress response group, with four miRNAs (miR-10400-5p, miR-1290, miR-6074-5p, and miR-9902) at higher levels and fourteen miRNAs (miR-203a-3p, miR-7-5p, miR-143-3p, miR-181a-5p, miR-142-5p, miR-223-5p, let-7f-5p, let-7g-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-26a-5p, miR-142-3p, and miR-21-5p) at lower levels. We also discovered sets of miRNAs that exhibited dynamic expression changes in response to intermediate and low stress. Functional enrichment analysis identified processes related to apoptosis, cellular response to stress, negative regulation of gene expression, responses to abiotic stimuli, positive regulation of catabolism as commonly regulated by the modulated miRNAs. Work-related stress response was associated with specific salivary miRNA expression patterns, with a general decrease of miRNA levels in the highly distressed police officers. These results suggest salivary miRNA profiling as a non-invasive and useful biomarker of stress and further characterize the link between chronic psychosocial stress and cellular and behavioral response mechanisms.

Dataset Information

Occupational hypersensitivity pneumonia.

Publications

Occupational hypersensitivity pneumonia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets