Dataset Information

TLR10: An intriguing Toll-like receptor with many unanswered questions.

ABSTRACT:

Background

Toll-like receptors (TLRs) are one of the first pattern recognition receptors (PRRs) found in the innate immune system. The TLR family has 12 members (TLR1-TLR9, TLR11-TLR13) in mice and 10 members (TLR1-TLR10) in humans, with TLR10 being the latest identified.

Summary

Considerable research has been performed on TLRs, however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, its function and signalling pathway are yet to be determined.

Key messages

This review gives an insight into recent findings on TLR10 pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor.

SUBMITTER: Rodrigues CR

PROVIDER: S-EPMC10861218 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions.

Rodrigues Carolina Rego CR Balachandran Yadu Y Aulakh Gurpreet Kaur GK Singh Baljit B

Journal of innate immunity 20240119 1

<h4>Background</h4>Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1-TLR9, TLR11-TLR13) in mice and 10 members (TLR1-TLR10) in humans, with TLR10 being the latest identified.<h4>Summary</h4>Considerable research has been performed on TLRs; however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing tow ...[more]

PMID: 38246135

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