Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
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ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC10864182 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Publications
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Meng Xiangrui X Navoly Georgina G Giannakopoulou Olga O Levey Daniel F DF Koller Dora D Pathak Gita A GA Koen Nastassja N Lin Kuang K Adams Mark J MJ Rentería Miguel E ME Feng Yanzhe Y Gaziano J Michael JM Stein Dan J DJ Zar Heather J HJ Campbell Megan L ML van Heel David A DA Trivedi Bhavi B Finer Sarah S McQuillin Andrew A Bass Nick N Chundru V Kartik VK Martin Hilary C HC Huang Qin Qin QQ Valkovskaya Maria M Chu Chia-Yi CY Kanjira Susan S Kuo Po-Hsiu PH Chen Hsi-Chung HC Tsai Shih-Jen SJ Liu Yu-Li YL Kendler Kenneth S KS Peterson Roseann E RE Cai Na N Fang Yu Y Sen Srijan S Scott Laura J LJ Burmeister Margit M Loos Ruth J F RJF Preuss Michael H MH Actkins Ky'Era V KV Davis Lea K LK Uddin Monica M Wani Agaz H AH Wildman Derek E DE Aiello Allison E AE Ursano Robert J RJ Kessler Ronald C RC Kanai Masahiro M Okada Yukinori Y Sakaue Saori S Rabinowitz Jill A JA Maher Brion S BS Uhl George G Eaton William W Cruz-Fuentes Carlos S CS Martinez-Levy Gabriela A GA Campos Adrian I AI Millwood Iona Y IY Chen Zhengming Z Li Liming L Wassertheil-Smoller Sylvia S Jiang Yunxuan Y Tian Chao C Martin Nicholas G NG Mitchell Brittany L BL Byrne Enda M EM Awasthi Swapnil S Coleman Jonathan R I JRI Ripke Stephan S Sofer Tamar T Walters Robin G RG McIntosh Andrew M AM Polimanti Renato R Dunn Erin C EC Stein Murray B MB Gelernter Joel J Lewis Cathryn M CM Kuchenbaecker Karoline K
Nature genetics 20240104 2
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS ...[more]
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