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Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study.

ABSTRACT: There is scarce data on energy expenditure in ill children with different degrees of malnutrition. This study aimed to determine resting energy expenditure (REE) trajectories in hospitalized malnourished children during and after hospitalization. We followed a cohort of children in Bangladesh and Malawi (2-23 months) with: no wasting (NW); moderate wasting (MW), severe wasting (SW), or edematous malnutrition (EM). REE was measured by indirect calorimetry at admission, discharge, 14-and-45-days post-discharge. 125 children (NW, n = 23; MW, n = 29; SW, n = 51; EM, n = 22), median age 9 (IQR 6, 14) months, provided 401 REE measurements. At admission, the REE of children with NW and MW was 67 (95% CI [58, 75]) and 70 (95% CI [63, 76]) kcal/kg/day, respectively, while REE in children with SW was higher, 79 kcal/kg/day (95% CI [74, 84], p = 0.018), than NW. REE in these groups was stable over time. In children with EM, REE increased from admission to discharge (65 kcal/kg/day, 95% CI [56, 73]) to 79 (95% CI [72, 86], p = 0.0014) and was stable hereafter. Predictive equations underestimated REE in 92% of participants at all time points. Recommended feeding targets during the acute phase of illness in severely malnourished children exceeded REE. Acutely ill malnourished children are at risk of being overfed when implementing current international guidelines.

SUBMITTER: Afroze F

PROVIDER: S-EPMC10864294 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study.

Afroze Farzana F Khoshnevisan Farnaz F Harawa Philliness Prisca PP Islam Zahidul Z Bourdon Celine C Khoswe Stanley S Islam Munirul M Sarker Shafiqul Alam SA Islam Farhana F Sayeem Bin Shahid Abu Sadat Mohammad ASM Joosten Koen K Hulst Jessie M JM Eneya Chisomo C Walson Judd L JL Berkley James A JA Potani Isabel I Voskuijl Wieger W Ahmed Tahmeed T Chisti Mohammod Jobayer MJ Bandsma Robert H J RHJ

Scientific reports 20240213 1

There is scarce data on energy expenditure in ill children with different degrees of malnutrition. This study aimed to determine resting energy expenditure (REE) trajectories in hospitalized malnourished children during and after hospitalization. We followed a cohort of children in Bangladesh and Malawi (2-23 months) with: no wasting (NW); moderate wasting (MW), severe wasting (SW), or edematous malnutrition (EM). REE was measured by indirect calorimetry at admission, discharge, 14-and-45-days p ...[more]

PMID: 38351162

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Project description:Background and aimsThe unique demographic and dietary characteristics of modern Arabic population require development of a new predictive equation for the estimation of resting energy expenditure (REE). This study presented new equations characteristic to Saudi population.MethodsA set of predictive equations for REE was derived for 427 healthy male and female subjects (aged 18-57 ± 14 years). REE was measured (REEm) by indirect calorimetry (IC) and predicted (REEp) using nine equations. REEp was compared with REEm to determine the predictive accuracy of these equations. Using IC and anthropometrics for stepwise linear regression analysis, a new set of equations to predict REE of men and women was developed. Accuracy of the new main equations was further tested in an external sample of 48 subjects (men = 50%).ResultsUsing a number of parameters (bias, underprediction, overprediction, and % accurate prediction), our results suggested that almost all (9/9 in men and 7/9 in women) equations either underpredicted or overpredicted (2/9) REE. None of the already existing equations showed an acceptable REEp/REEm difference as low as 5% and an accurate prediction (∼55%) at the individual level. Based on these findings, a new prediction equation (hereafter referred to as the Almajwal-Abulmeaty (AA) equation) was developed using this study's data, after a rigorous stepwise regression analysis using the following formula: REE = 3832.955 + AdjWt (kg) × 48.037 - Ht (cm) × 30.642 + gender × 141.268 - age (years) × 4.525 [AdjWt is Adjusted body weight = (Wt - IBW)/4 + IBW. IBW is Ideal body weight; for men IBW = (Ht(cm) - 152.4) × 1.0714) + 45.36 and for women IBW = (Ht(cm)-152.4) × 0.8928) + 45.36]. The regression model accounted for approximately 70% of the variance in REEm (R 2 = 0.702).ConclusionPrevious equations likely over- or underpredicted REE. Therefore, the new predictive AA equations developed in this study are recommended for the estimation of REE in young to middle-aged Saudi men and women with different body mass indexes. Future research is also required for further clinical and cross-validation of these new equations.

Dataset Information

Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study.

Publications

Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study.

Similar Datasets

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