Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC10864387 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Zhang Yi Y Wang Mingjie M Ye Ling L Shen Shengqi S Zhang Yuxi Y Qian Xiaoyu X Zhang Tong T Yuan Mengqiu M Ye Zijian Z Cai Jin J Meng Xiang X Qiu Shiqiao S Liu Shengzhi S Liu Rui R Jia Weidong W Yang Xianzhu X Zhang Huafeng H Zhong Xiuying X Gao Ping P
Nature communications 20240213 1
Immune checkpoint blockade (ICB) has shown considerable promise for treating various malignancies, but only a subset of cancer patients benefit from immune checkpoint inhibitor therapy because of immune evasion and immune-related adverse events (irAEs). The mechanisms underlying how tumor cells regulate immune cell response remain largely unknown. Here we show that hexokinase domain component 1 (HKDC1) promotes tumor immune evasion in a CD8<sup>+</sup> T cell-dependent manner by activating STAT1 ...[more]